NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES

摘要

The present invention relates to novel kidney related polynucleotides and th e polypeptides encoded by these polynucleotides herein collectively known as "kikdney antigens", and the use of such kidney antigens for detecting disorders of the kidney, particularly the presence of kidney cancer and kidn ey cancer metastases. More specifically, isolated kidney associated nucleic aci d molecules are provided encoding novel kidney associated polypeptides. Novel kidney polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthet ic methods for producing human kidney associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the kidney, including kidney cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotide s and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of th e polypeptides of the present invention.