发明名称 |
ARYLPIPERAZINE COMPOUND AND PRODUCING METHOD THEREOF |
摘要 |
PURPOSE: An arylpiperazine compound and a producing method thereof are provided. The arylpiperazine compound can label technetium and F-18 with no having disadvantages of prior arts. CONSTITUTION: The arylpiperazine compound is represented by formula (1), in which R is methanesulfonyl, paratoluenesulfonyl or trifluoromethanesulfonyl. A compound of formula (1a) is produced by treating a compound of formula (7) with mesyl chloride under triethylamine. A compounds of formula (1b) is produced by reacting a compound of formula (13) with sodium hydrogen and the compound of formula (7) to produce a compound of formula (14); and dissolving the compound of formula (14) in anhydrous anisole and reacting with anhydrous trifluoro acetic acid, in which the compound of formula (13) is produced by dissolving a compound of formula (9) into trifluoro acetic acid and reacting with triphenylmethanol to produce a compound of formula (10); reacting the compound of formula (10) with triethylamine and bromoacetyl bromide to produce a compound of formula (11); reacting the compound of formula (11) with triphenylmethanol under trifluoro acetic acid to produce a compound of formula (12); and reacting the compound of formula (12) with 3-bromopropionyl chloride. The formula (1b), (9) to (14) are described as in the description.
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申请公布号 |
KR20010073625(A) |
申请公布日期 |
2001.08.01 |
申请号 |
KR20000002389 |
申请日期 |
2000.01.19 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
BYUN, JONG SU;CHO, JEONG HYEOK;LEE, GI SU;LEE, SUK JA;OH, CHANG HYEON;OH, CHANG SEOK |
分类号 |
C07D401/12;(IPC1-7):C07D401/12 |
主分类号 |
C07D401/12 |
代理机构 |
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