| 摘要 |
The present invention provides novel isolated polypeptides chosen from among a) a syncollin-like protein having a syncollin-like activity; b) a novel polypeptide whose amino acid sequence is given by or is similar to SEQ ID NO:6; c) a claudin-like protein having a claudin-like activity; d) a cytokine-like protein whose amino acid sequence has at least 80 % identity to human GRO-beta and having a GRO-beta-like activity, and e) a fragment of any of them; as well as polynucleotides encoding them and antibodies that immunospecifically bind to them. The invention additionally provides several methods in which these proteins, polynucleotides and antibodies are used in methods of detection and methods of treatment are also disclosed. These methods additionally include methods employing proteins, polynucleotides and antibodies related to the additional substances a cysteine-rich soluble protein, and a mammaglobin homologue/endometrial specific steroid-binding factor III. These methods of detection and treatment are directed to a broad range of pathological states. |
