| 摘要 |
It has been demonstrated that conjugated linoleic acid isomers with the first double bond in position 9 (<I>cis</I>) or 10 (<I>trans</I>), added exogenously, can be desaturated in position 6 by the cyanobacterium <I>Spirulina platensis</I>. The metabolites, 6-<I>cis</I>,9-cis,11-<I>trans</I>-octadecatrienoic and 6-<I>cis</I>, 10-<I>trans</I>, 12-<I>cis</I>-octadecatrienoic acids, which have not previously been characterized, were isolated by a combination of chromatographic techniques and the structures were confirmed by gas chromatography-mass spectrometry in the form of picolinyl ester and dimethyloxazoline derivatives. Octadeca-6,9-dien-12-ynoic acid was synthesised in a similar manner from the substrate octadeca-9-en-12-ynoic acid. Pharmaceutical compositions containing the compounds of the invention as well as their use for the inhibition of one or more actions of arachidonic acid are disclosed. |
