发明名称 |
2-AMINO-NICOTINAMIDE DERIVATIVES AND THEIR USE AS VEGF-RECEPTOR TYROSINE KINASE INHIBITORS |
摘要 |
The invention relates to the use of 2-amino-nicotinamide derivatives of formula (I) wherein n is from 1 up to and including 6; W is O or S; R1 and R3 represent independently of each other hydrogen, lower alkyl or lower acyl; R2 represents a cycloalkyl group, an aryl group, or a mono- or bicyclic heteroaryl group comprising one or more ring nitrogen atoms and 0, 1 or 2 heteroatoms independently from each other selected from the group consisting of oxygen and sulfur, which groups in each case are unsubstituted or mono- or polysubstituted; R and R' are independently of each other hydrogen or lower alkyl; X represents an aryl group, or a mono- or bicyclic heteroaryl group comprising one or more ring nitrogen atoms and 0, 1 or 2 heteroatoms independently from each other selected from the group consisting of oxygen and sulfur, which groups in each case are unsubstituted or mono- or polysubstituted; or a N-oxide, a possible tautomer thereof or a pharmaceutically acceptale salt of such a compound, alone or in combination with one or more other pharmaceutically active compounds for the preparation of a pharmaceutical composition for use for therapy of a disease which responds to an inhibition of the VEGF-receptor tyrosine kinase activity; and to new 2-amino-nicotinamide derivatives of formula (I) and processes for the preparation thereof.
|
申请公布号 |
WO0155114(A1) |
申请公布日期 |
2001.08.02 |
申请号 |
WO2001EP00835 |
申请日期 |
2001.01.25 |
申请人 |
NOVARTIS AG;NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.;MANLEY, PAUL, WILLIAM;BOLD, GUIDO |
发明人 |
MANLEY, PAUL, WILLIAM;BOLD, GUIDO |
分类号 |
A61K31/44;A61K31/444;A61K31/445;A61K31/4725;A61P3/10;A61P5/30;A61P17/00;A61P27/02;A61P35/00;A61P43/00;C07D213/82;C07D213/89;C07D401/14;C07D417/14;(IPC1-7):C07D213/82;A61K31/455 |
主分类号 |
A61K31/44 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|