发明名称 |
Vaccine production of the Bacillus anthracis protective antigen |
摘要 |
Methods of preparing recombinant Bacillus anthracis protective antigen or a variant or fragment thereof for use in vaccines is disclosed. The protein is expressed in a recombinant microorganism which comprises a sequence which encodes PA or said variant or fragment thereof wherein either (i) a gene of the microorganism which encodes a catabolic repressor protein and/or AbrB is inactivated, and/or (ii) wherein a region of the PA sequence which can act as a catabolic repressor binding site and/or an AbrB binding site is inactivated. Useful quantities of protein are obtainable from these organisms.
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申请公布号 |
US6267966(B1) |
申请公布日期 |
2001.07.31 |
申请号 |
US19990242846 |
申请日期 |
1999.02.25 |
申请人 |
THE SECRETARY OF STATE FOR DEFENCE |
发明人 |
BAILLIE LESLIE W J |
分类号 |
A61K39/00;A61P31/04;C07K14/32;C12N1/21;C12N15/31;(IPC1-7):A61K39/295 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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