| 摘要 |
Compounds comprisinga straight backbone carbon chain of 8-16C, optionally substituted with 1-5 alkyl groups (1-6C);said chain optionally functionalized at one terminus with halo, -OR, -SR, -NR2, -OOCR, -NROCR wherein R is alkyl (1-6C), or phosphate or pyrophosphate, or functionalized wherein a terminal carbon is optionally in the form of -COOR, -CONR2 or -COR wherein R is alkyl (1-6C); andwherein said chain may optionally contain 1-pi-bonds or the epoxides thereofare useful as calcium channel inhibitors. Libraries of these compounds can also be used to identify antagonists for other targets.
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