MUTATED PHOSPHOENOLOPYROGRONIANIC CARBOXYLASE, ITS GENE AND METHOD OF OBTAINING AMINO ACID

摘要

A variant phosphoenolpyruvate carboxylase that is not substantially inhibited by aspartic acid is produced by introducing a variant phosphoenolpyruvate carboxylase gene, such as one wherein the 625th glutamic acid residue from the N-terminus of the carboxylase has been replaced by a lysine residue or one wherein the 438th arginine residue has been replaced by a cysteine residue, into Escherichia coli or a coryneform bacterium. An amino acid can efficiently be produced by using this carboxylase.