发明名称 |
Antidepressant 3-Halophenylpiperazinyl-propyl Derivatives of Substituted Triazolones and Triazoldiones. |
摘要 |
<p>Compounds of Formula I <CHEM> or a pharmaceutically acceptable acid addition salt and/or hydrate thereof wherein R is halogen and trifluoromethyl; X is oxygen and acetyl; the single and dotted lines represent either a covalent single or double bond; n is an integer from 2 to 4; and Z is hydrogen and <CHEM> in which R<1> is hydrogen, halogen, C1-4 alkoxy and trifluoromethyl, which are psychotropic agents having promise as antidepressants by virtue of their receptor site binding affinity profiles and animal pharmacology.</p> |
申请公布号 |
GR3035809(T3) |
申请公布日期 |
2001.07.31 |
申请号 |
GR20010400657T |
申请日期 |
2001.04.27 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
MAYOL, ROBERT F.;LUKE, GEORGE M. |
分类号 |
A61K31/495;A61P25/24;A61P25/26;C07D249/12;(IPC1-7):C07D249/12;A61K31/41 |
主分类号 |
A61K31/495 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|