New crystalline citalopram base, useful as an antidepressant and as intermediate in the production of crystalline citalopram salts

摘要

Crystalline citalopram base is new. Crystalline base of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo furancarbonitrile) of formula (I) is new: Independent claims are also included for the crystalline salt of (I), prepared by: (i) liberating the base of (I), preferably from a crude salt, especially from a crude solution of (I)-base or salt; (ii) precipitating the base in crystalline form; and (iii) converting into the salt.