Nitrogenous cyclic compounds and pharmaceutical compositions containing the same

摘要

The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted C3-14 hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula -CO-, etc.; X indicates a single bond, an oxygen atom etc.; R<1> indicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D<1>, D<2>, W<1> and W<2> are the same as or different from each other and each represents a single bond or an optionally substituted C1-6 alkylene chain.