PROCEDIMIENTO PARA LA OBTENCION DE 9-(AMINOALQUILO)-9, 10- DIHIDRO-9, 10-ETANOANTRACENOS SUSTITUIDOS.

摘要

1,266,889. Ethanoanthracenes. CIBAGEIGY A.G. 30 April, 1969 [16 May, 1968; 25 March, 1969], No. 21967/69. Heading C2C. 9 - Aminoalkyl - 9,10 - dihydro - 9,10 - ethanoanthracenes containing a free or acylated hydroxy group or an oxo atom at position 12 and their salts are prepared by standard methods, e.g. (a) in a corresponding compound containing at position 9 a radical X convertible to an aminoalkyl group, X is so converted, (b) reduction of a corresponding 61,11,31,41- tetrahydro - 61,10 - methanospiro[anthracene- 9(10H),51(21H)[1,3]oxazine], (c) oxidation of a 12-hydroxy compound, (d) reduction of a 12- oxo compound, (e) hydrolysis or reduction of a 12-acyloxy compound or (f) acylation, optionally followed in each case by isomer separation and/ or salt formation. The preparation of 9-acetamidomethyl-12- hydroxy - 9,10 - dihydro - 9,10 - ethanoanthracene, 12 - acetoxy - 9,10, - dihydro - 9,10 - ethano - 9- anthraldehyde, 9 - (N - ethylacetamidomethyl)-12- hydroxy - 9,10 - dihydro - 9,10 - ethanoanthracene, 9 - benzyliminomethyl - 12 - acetoxy - 9,10- dihydro - 9,10 - ethanoanthracene, N - methyl - #- (12 - hydroxy - 9,10 - dihydro - 9,10 - ethano - 9- anthryl)propionamide, ethyl α - cyano - # - (12- acetoxy - 9,10 - dihydro - 9,10 - ethano - 9 - anthryl)acrylate, ethyl α - cyano - # - (12 - acetoxy- 9,10 - dihydro - 9,10 - ethano - 9- anthryl)propionate, # - (12 - hydroxy - 9,10 - dihydro - 9,10- ethano - 9 - anthryl) - propiolactone and 9- acetamidomethyl - 12 - oxo - 9,10 - dihydro - 9,10- ethanoanthracene is described. The above compounds which are N-substituted possess psychotropic activity, and may be administered in the form of pharmaceutical or veterinary preparations containing them in association with a carrier.