发明名称 Cancer treatments
摘要 The present invention is to a method of treating cancer in patients in need thereof with an effective amount of cimetidine. Cimetidine has been found to inhibit the expression of E-selectin, the ligands of sialyl Lewis X and sialyl Lewis A antigen-bearing cancer cells are incapable of attaching to a vascular wall. The present invention has found that cimetidine inhibits metastasis in patients whose specimens stained strongly for sialyl Lewis X and sialyl Lewis A antigens.
申请公布号 US6268156(B1) 申请公布日期 2001.07.31
申请号 US19980158936 申请日期 1998.09.22
申请人 SMITHKLINE BEECHAM SEIYAKU K.K. 发明人 MATSUMOTO SUMIO;KOBAYASHI KENICHI;OKAMOTO TAKASHI
分类号 C07D233/64;A61K31/00;A61K31/415;A61K31/4164;A61P35/00;A61P35/04;G01N33/574;(IPC1-7):G01N33/53;G01N33/567;G01N33/48;A01N43/42;A61K31/47 主分类号 C07D233/64
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