发明名称 |
Cancer treatments |
摘要 |
The present invention is to a method of treating cancer in patients in need thereof with an effective amount of cimetidine. Cimetidine has been found to inhibit the expression of E-selectin, the ligands of sialyl Lewis X and sialyl Lewis A antigen-bearing cancer cells are incapable of attaching to a vascular wall. The present invention has found that cimetidine inhibits metastasis in patients whose specimens stained strongly for sialyl Lewis X and sialyl Lewis A antigens.
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申请公布号 |
US6268156(B1) |
申请公布日期 |
2001.07.31 |
申请号 |
US19980158936 |
申请日期 |
1998.09.22 |
申请人 |
SMITHKLINE BEECHAM SEIYAKU K.K. |
发明人 |
MATSUMOTO SUMIO;KOBAYASHI KENICHI;OKAMOTO TAKASHI |
分类号 |
C07D233/64;A61K31/00;A61K31/415;A61K31/4164;A61P35/00;A61P35/04;G01N33/574;(IPC1-7):G01N33/53;G01N33/567;G01N33/48;A01N43/42;A61K31/47 |
主分类号 |
C07D233/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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