NOVEL CYCLIN DEPENDENT KINASE(CDK) INHIBITORS HAVING FLAVONE STRUCTURE

摘要

PURPOSE: Provided are a novel flavone derivative, pharmaceutically acceptable salt, hydrate, solvate and isomer thereof which are useful as an inhibitor against Cyclin Dependent Kinase (CDK). And a process for preparation thereof, and a composition of anti-cancer agent or agent for treating neurodegenerative disease comprising these compounds as an active ingredient are also provided. CONSTITUTION: Provided is a novel flavone derivative which is used as a CDK inhibitor and represented by the formula(1). In the formula(1), R1, R3, and R4 are independently hydrogen, halogen, hydroxy group, alkyl, low alkoxy, amino or nitro; R2 is hydrogen, halogen, hydroxy, low alkoxy, low alkyl, amino, nitro or A-Y-N-B, wherein A is amino substituted with alkyl, cycloalkyl, aralkyl, acyl or aryl, the aryl is substituted with 1-2 substituents selected from the group consisting of halogen, cyano, nitro, and amino; or 1,2,3,4-tetrahydroisoquinoline substituted with halogenoalkylcarbonyl; or represents alkyl, aryl, aralkyl or heteroaryl which are independently substituted with 1-2 substituents selected from the group consisting of alkyl, halogenoalkyl, halogen, dialkylamino, phenyl, nitro, amino, isooxazole, pyridine, carboxymorpholine, methylpiperazine and cyano; Y is SO2 or CO; B is hydrogen or alkyl; R5 is hydrogen or hydroxy; R6 and R7 are substituted mutually at o,m, or p position, and independently represent hydrogen, hydroxy, halogen or low alkoxy or represent low alkylendioxy together.