| 摘要 |
The use of one or several compounds selected from the group of sodium, potassium, calcium, magnesium, zinc and iron salts of fumeric acid monoalkyl esters of formula (1), optionally in combination with dialkyl fumerate of formula (2) wherein; A is a bivalent cation from the series containing Ca, Mg, Zn, or Fe or a monovalent cation from the series consisting of potassium or sodium respectively, and n denotes the numeral 1 or 2 depending on the type of cation, or one or several of the compounds from the series consisting of alkyl hydrogen fumerates formula (3), optionally in combination with dialkyl fumerate of formula (4), in pharmaceutical compositions. The compositions is useful in treating auto-immune diseases selected from the group consisting of polyarthritis, multiple sclerosis, graft-versus-host reactions, juvenile diabetes, Hashimoto tyroiditis, Grave's diseases, systemic Lupus erythaematodes (SLE), Sjogren's Syndrome, pernicious anaemia and chronic active (lupoid) hepatitis.
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