A METHOD FOR DETECTING AN ABERRANT ANIMAL-DERIVED PRION GENEAND A PRION GENE MODIFIED MOUSE WHICH EXHIBITS HEART ANOMALIES

摘要

The present invention relates to a method for detecting an aberrant animal- derived prion gene wherein the method comprises steps of introducing a prion gene of an animal into a mouse to produce a prion gene modified mouse and determining that the prion gene is aberrant when the prion gene modified mouse exhibits heart anomalies; a prion gene modified mouse which exhibits heart anomalies; and a method for detecting drugs which reduc e abnormal waves in an electrocardiogram of the mouse.