(S) 2-methylamino-2-phenyl-n-butyl 3,4,5-trimethoxybenzoate and its application to the treatment of chronic pain

摘要

Optically pure (S) 2-methylamino-2-phenyl-n-butyl 3,4,5-trimethoxybenzoate having formula (I) is provided. (S) 2-formylamino-2-phenyl-n-butyric acid is reduced with a hydride derived from boron in order to obtain (S) 2-methylamino-2-phenyl-n-butanol, which is then esterified with a reagent chosen from 3,4,5-trimethoxybenzoyl chloride or methyl 3,4,5-trimethoxybenzoate in order to obtain the compound of formula (I). The compound of formula (I) may be used in pharmaceutical compositions for the treatment of chronic pain.