发明名称 |
USE OF PRO-APOPTOTIC FACTORS IN TREATMENT OF ATHEROSCLEROSIS |
摘要 |
The present invention features a novel method of treating vascular disease that involves modifying smooth muscle cells to express a gene encoding a protein having both anti-inflammatory and pro-apoptotic activity. Preferably, the protein of the invention also has an anti-proliferative effect in smooth muscle cells. In general, the method is useful in preparing vascularized organs and vessels for transplant into a patient. Alternatively, the present invention can be applied to treat atherosclerotic lesions in damaged vessels.
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申请公布号 |
WO0152639(A1) |
申请公布日期 |
2001.07.26 |
申请号 |
WO2001US01894 |
申请日期 |
2001.01.19 |
申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER |
发明人 |
FERRAN, CHRISTIANE;ARVELO, MARIA, B. |
分类号 |
A61K35/12;A61K38/17;A61K38/19;A61K48/00;C12N5/071;C12N5/077;(IPC1-7):A01K61/00;A01K63/00;A01K1/00;C12N5/00;C12N5/02;C12N15/00 |
主分类号 |
A61K35/12 |
代理机构 |
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地址 |
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