AN IN VIVO SCREEN USING CHEMICAL INDUCERS OF DIMERIZATION

摘要

The subject of the invention provides a compound having the formula: H1-X-B- Y- H2, wherein each of H1 and H2 may be the same or different and capable of binding to a receptor which is the same or different; wherein each of X and Y may be present or absent and if present, each may be the same or different spacer moiety; and wherein B is an enzyme cleavable moiety. Said compounds c an be called chemical inducers of dimerization. This invention also provides a method of screening proteins for the ability to catalyze bond cleavage.