NOVEL ORTHOGONALLY PROTECTED AMINO ACID CHELATORS FOR BIOMEDICAL APPLICATIONS

摘要

Polyazacarboxylates and their peptide conjugates which are useful for imaging, diagnosis and therapy are disclosed. Particularly, this invention relates to compositions of two or more peptides that are conjugated to a molecule of polyazacarboxylate ligand. The compounds of this invention are in the general formula (1): R1NHC(O)-LS-C(O)NHR2, wherein R1 and R2 are peptides with the same or different receptor affinities and LS is a cyclic or linear polyazacarboxylates. The are useful for therapeutic and contrast agents in biomedical applications.