| 摘要 |
<p>The present invention provides recombinant flaviviruses, particularly live attenuated recombinant flavivirus, which comprise exogenous nucleotide sequences which encode exogenous amino acid sequences. These recombinant flavivirus viruses comprise an exogenous nucleic acid. Infection of a host cell with a recombinant flavivirus provides for expression of the exogenous nucleic acid in a host cell and production of an antigenic polypeptide encoded by the exogenous nucleic acid. Such recombinant flavivirus are useful in eliciting an immune response to the exogenous polypeptide.</p> |
