发明名称 |
NEW COCHLEATE FORMULATIONS, PROCESS OF PREPARATION AND THEIR USE FOR THE DELIVERY OF BIOLOGICALLY RELEVANT MOLECULES |
摘要 |
A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca<2+> or Zn<2+>, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
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申请公布号 |
WO0152817(A2) |
申请公布日期 |
2001.07.26 |
申请号 |
WO2001US02299 |
申请日期 |
2001.01.24 |
申请人 |
BIODELIVERY SCIENCES, INC.;UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY |
发明人 |
ZARIF, LEILA;JIN, TUO;SEGARRA, IGNACIO;MANNINO, RAPHAEL, J. |
分类号 |
A23L1/30;A61K9/00;A61K9/127;A61K9/72;A61K31/07;A61K31/122;A61K31/19;A61K31/197;A61K31/355;A61K31/593;A61K31/70;A61K31/7004;A61K31/7016;A61K33/06;A61K33/26;A61K33/30;A61K47/02;A61K47/24;A61K47/30;A61K47/34;A61K47/46;A61K47/48;A61P3/02;(IPC1-7):A61K9/127 |
主分类号 |
A23L1/30 |
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地址 |
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