| 摘要 |
The present invention relates to a nasally administrable composition of a physiologically active cyclic peptide and pharmaceutically acceptable salts thereof that is prepared by homogeneously dispersing a physiologically activ e cyclic peptide such as antifungal cyclic peptides (aerothricings, echinocand in analogs, pneumocandin analgos, and auroebacidines), antibacterial cyclic peptides (e.g. vancomycin, daptomycin), cyclosporin A, lanreotide, vapreotid e, vasopressin antagonist (US 5,095,003) and eptifibatide in unique carrier, i. e. a physiologically acceptable powdery or crystalline carrier containing a wat er insoluble polyvalence metal carrier, or organic carrier having a mean partic le size of 20 to 500 .mu.m, in the presence or absence of an absorption enhance r and by homogeneously adsorbing onto the carrier, and its use for therapeutic treatment of disease such as systemic fungal infections by intranasal administration. The composition can be nasally administered in powder form.< /SDOAB>
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