发明名称 New phenylamidine compounds are useful for the treatment of thrombosis, cerebrovascular disorders, heart infarction, arteriosclerosis, osteoporosis, tumor metastasis, shock and diabetes
摘要 Phenylamidine compounds (I), their salts, tautomers or stereoisomers are new. Phenylamidine compounds of formula (I), their salts, tautomers or stereoisomers are new. [Image] R6OH, 1-18C alkoxycarbonyl, arylcarbonyl or aryl-(1-4C alkoxy)carbonyl; R7H, 1-8C alkyl, 4-7C cycloalkyl, phenyl-(1-4C alkyl) or R8-CO-OCHR9; R81-4C alkyl, 1-4C alkoxy, 3-7C cycloalkyl or 4-7C cycloalkoxy; R9H or 1-4C alkyl; All the aryl moieties described above are phenyl monosubstituted by R10, mono- di- or trisubstituted by R11 or monosubstituted by R10 and mono- or disubstituted by R11; R10CN, COOH, 1-4C alkoxycarbonyl, aminocarbonyl, 1-4C alkylaminocarbonyl, di-(2-4C alkyl)aminocarbonyl, 1-4C alkylsulfenyl, 1-4C alkylsulfinyl, 1-4C alkylsulfonyl, OH, 1-4C alkylsulfonyloxy, OCF3, NO2, NH2, mono- or di-(1-4C alkyl)amino, (1-4C alkyl)carbonylamino, N-(1-4C alkyl)-(1-4C alkyl)sulfonylamino, aminosulfonyl, mono- or di-(1-4C alkyl)aminosulfonyl or carbonyl substituted by a 5-7 membered alkyleneimino group whose 4-methylene group may be replaced by a heteroatom or hetero group; R11F, Cl, Br, I, alkyl, CF3 or 1-4C alkoxy; Or two adjacent R11 groups together form 3-5C alkylene, methylenedioxy or 1,3-butadien-1,4-ylene. - ACTIVITY : Thrombolytic; cerebroprotective; anticoagulant; cardiant; antiarteriosclerotic; osteopathic; cytostatic; vasotropic; antipsoriatic; antidiabetic; antiinflammatory. No biological data given. - MECHANISM OF ACTION : Antimetastatic.
申请公布号 DE10002510(A1) 申请公布日期 2001.07.26
申请号 DE20001002510 申请日期 2000.01.21
申请人 BOEHRINGER INGELHEIM PHARMA KG 发明人 HIMMELSBACH, FRANK;GUTH, BRIAN
分类号 C07D295/14;A61K31/495;A61P7/02;A61P9/10;A61P19/08;A61P35/00;A61P43/00;C07D295/15;(IPC1-7):C07D295/10;C07D295/12 主分类号 C07D295/14
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