| 摘要 |
<p>A mutant cholera holotoxin featuring a point mutation at amino acid 29 of the A subunit, wherein the glutamic acid residue is replaced by an amino acid other than aspartic acid, is useful as an adjuvant in an antigenic composition to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus or parasite. In a particular embodiment, the amino acid 29 is histidine. The mutant cholera holotoxin may contain at least one additional mutation in the A subunit at a position other than amino acid 29. The antigenic composition may include a second adjuvant in addition to the mutant cholera holotoxin.</p> |
| 申请人 |
AMERICAN CYANAMID COMPANY;THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES |
发明人 |
HOLMES, RANDALL, K.;JOBLING, MICHAEL, G.;ELDRIDGE, JOHN, H.;GREEN, BRUCE, A.;HANCOCK, GERALD, E.;PEEK, JOEL, A. |
