Method to identify agents active against HCV by using the structure coordinates of hepatitis C virus protease

摘要

The invention relates to methods of using the structure coordinates of hepatits C virus protease in complex with a synthetic NS4A to evaluate the potential of a chemical entity to associate with a molecule or molecular complex comprising a binding pocket of tNS3 or to identify a potential agonist or antagonist of a molecule comprising a NS3-like binding pocket.