| 摘要 |
This invention relates to novel aryl substituted azabenzimidazoles of Formul a (I) and pharmaceutically acceptable salts thereof. (see formula I) or a pharmaceutically acceptable salt thereof wherein n is an integer from 1 to 4 X is CH or N; R1 is H, (C1-C6)alkyl or (C1-C6) alkoxy; R2 is H, (C1-C6)alkyl or (C1-C6) alkoxy; each R3 is independently selected from H, (C1-C6)alkyl (C1-C6) alkyloxy, (C1 - C6) alkylthio, halo, nitro, cyano, ethynyl, hydroxyand trifluoromethyl; R4 is H, (C1-C6)alkyl or (C1-C6) alkoxy; R5 is H, (C1-C6)alkyl or (C1-C6) alkyloxy, trifluoromethyl; and W is N or C; Y is N (R4), N, S or O Z is R4, NR4H, O, or OH; Provided that when Y = NR4, W = C, Z = O, there is a single bond between YW and a double bond between WZ; and when Y = O or S, W = C, Z = O, there is a single bond between YW and a doubl e bond between WZ; and when Y = N, W = N, there is a double bond between YW and Z does not exist. when Y = N, W = C, Z = R4 or NHR4, there is a double bond between YW and a single bond between WZ; The methods of preparing these compounds and their u se in the treatment of HIV, AIDS, and AIDS related diseases and in slowing the progression of HIV infection into AIDS is also disclosed.
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