发明名称 |
Chromosome 9 and progressive rod-cone degeneration disease genetic markers and assays |
摘要 |
Provided are nucleic acid molecules which comprise at least a portion of a polymorphic genetic marker for determining whether a canine has a mutated progressive rod-cone degeneration disease (prcd) gene locus in one or both alleles. The genetic markers are located on canine chromosome 9 in a genomic region identified as the prcd-informative region. A method for making genetic markers representing polymorphic sequences located in the prcd-informative region of canine chromosome 9 comprises isolating a polymorphic DNA sequence in the prcd-informative region, using oligonucleotides complementary with at least a portion of the sequence to amplify the sequence, and analyzing canine chromosome 9 in a prcd-informative pedigree for the ability of the polymorphic sequence to co-segregate with the prcd gene locus by a linkage test. The presence of a mutated prcd gene locus in one or both alleles of a canine in a pedigree is detected by analyzing canine chromosome 9 in the canine for the presence of at least one polymorphic genetic marker, which co-segregates with the prcd gene locus, by a linkage analysis. |
申请公布号 |
GB2341926(B) |
申请公布日期 |
2001.07.25 |
申请号 |
GB20000000458 |
申请日期 |
1998.06.08 |
申请人 |
* CORNELL RESEARCH FOUNDATION INC |
发明人 |
GUSTAVO * AGUIRRE;GREGORY * ACLAND;KUNAL * RAY |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/68;C12P19/34;C07H21/04 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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