| 摘要 |
PURPOSE: Provided is an improved process for the synthesis of mercaptomethylphenols with reduced smell, with reduced discoloration in the presence of for example lithium catalysts and alkaline medium, and with excellent storage stability. CONSTITUTION: The improved process for the preparation of a compound of the formula(1) (wherein n is 0 or 1, R1 is C1-C12 alkyl or -CH2SR3, R2 is C1-C12 alkyl, C7-C9 phenylalkyl, C7-C9-phenylalkyl substituted on the phenyl radical by from 1 to 3 C1-C4 alkyl groups; or -CH2SR3, R3 is C6-C18 alkyl, phenyl or benzyl, R4 is hydrogen or methyl, R5 is hydrogen or methyl, with the proviso that R4 and R5 are not simultaneously methyl), comprises (i) reacting a compound of the formula(2) (wherein n, R4 and R5 are as previously defined, R11 is hydrogen or C1-C12 alkyl; and R12 is hydrogen, C1-C12 alkyl, C7-C9 phenylalkyl, C7-C9 phenylalkyl substituted on the phenyl radical by from 1 to 3 C1-C4 alkyl groups) with formaldehyde or a compound that liberates formaldehyde under the reaction conditions and with at least one compound of the formula:R3SH (wherein R3 is as previously defined), in the presence of a base, the base being mono- or dimethylamine or mono- or diethylamine, (ii) treating afterwards the reaction product with a reducing agent.
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