| 摘要 |
Proteins containing one or more disulfide bonds are radiolabeled with radionuclides of technetium or rhenium for use in diagnosis and treatment of a variety of pathologic conditions. Radiolabeling is accomplished by partial reduction of the disulfide bonds of he protein using Sn (II), or using other seducing agents followed b y the addition of Sn (II), removal of excess reducing agent and reduction by-products; and addition of a specified amount of pertechnetate or perrhenate reducing agent, such as stan- nous tartrate; with the addition accomplished in such a manner that further reduction of the protein is limited. The,resulting pro- duct may be stored frozen or lyophilized, with radiolabeling accomplished by the addition of pertechnetate ar perrhenate solu- tion.
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