Methods of regulating IL-12 production by administering CCR5 agonists and antagonists

摘要

The present invention provides a method for increasing IL-12 production in a cell, comprising administering a CCR5 agonist to the cell. The invention also provides a method for decreasing IL-12 production in a cell, comprising administering a CCR5 antagonist to the cell. Further provided by this invention is a method for treating a disease associated with increased IL-12 production in a subject, comprising administering to the subject a CCR5 antagonist in an amount effective in reducing the disease-associated effect of IL-12, thereby treating the disease associated with increased IL-12 production. Also provided by this invention is a method for increasing IL-12 production in a subject, comprising administering and effective amount of a CCR5 agonist to the subject.