| 发明名称 |
Pyrrolidine modulators of chemokine receptor activity |
| 摘要 |
The present invention is directed to pyrrolidine compounds of the formula 1:(wherein R1, R2, R3, R4, R5, R6 and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
|
| 申请公布号 |
US6265434(B1) |
申请公布日期 |
2001.07.24 |
| 申请号 |
US20000543024 |
申请日期 |
2000.04.04 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
CALDWELL CHARLES;CHAPMAN KEVIN T.;HALE JEFFREY;KIM DOOSEOP;LYNCH CHRISTOPHER;MACCOSS MALCOLM;MILLS SANDER G.;ROSAUER KEITH;WILLOUGHBY CHRISTOPHER;BERK SCOTT |
| 分类号 |
A61K31/454;A61K31/4545;A61K31/4709;A61K31/497;A61K31/498;A61K31/501;A61K31/506;A61P1/00;A61P3/10;A61P9/10;A61P11/02;A61P11/06;A61P17/00;A61P19/02;A61P21/04;A61P27/14;A61P29/00;A61P31/18;A61P33/10;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07D401/06;C07D401/14;C07D405/14;C07D409/14;C07D413/14;C07D417/14;C07D471/04;C07D471/06;C07D495/04;(IPC1-7):A61K31/40;A61K31/445;C07D211/00;C07D409/00;C07D207/00 |
主分类号 |
A61K31/454 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
