METHOD OF PRODUCING CYCLIC POLYETHER

摘要

PROBLEM TO BE SOLVED: To provide a method for synthesizing a convergent cyclic polyether skeleton that is applicable to the synthesis of ciguatoxin and further applicable to cyclic compounds larger than six-membered rings. SOLUTION: An alkyl borane and a cyclic enol phosphate are crosscoupled in a basic aqueous solution by using a palladium (0) compound bearing phosphine ligands as a catalyst.