| 摘要 |
PROBLEM TO BE SOLVED: To enable the removal of finely divided particles such as coloring matter, the concentration of collagen and the removal of added pepsin or the like and to realize mass production in an inexpensive equipment with pollution of outside excluded by employing and adding new purification and concentration processes because it is clifficult to put the present method for producing collagen from salmon, etc., into practical use due to the thinness of salmon skin leading to the impossibility of physically removing impurity-containing epidermis alone and therefore to both of the impossibility of mass production and the expensiveness of equipment because of finally performing the removal of impurities by an ultracentrifuge. SOLUTION: It is the same way as a conventional one that a preprocessing process for degreasing and cleansing skins of marine organisms is followed by an extracting process for extracting collagen with an organic acid and also making it atheromatous using pepsin, etc. Then, a purified collagen solution is obtained by a purifying process for removing impurities from the crude collagen solution obtained there and for making the solution pass through a purification membrane. The collagen solution is applied with a concentrating process for making it pass through a concentration membrane and is finally applied with a conventional filtration process for sterilization to obtain a product of soluble collagen in enzyme.
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