MIXING PROCESS FOR CIMICIFUGAE RHIZOMA EXTRACT AND MIXED COMPOSITION THEREOF

摘要

PURPOSE: A mixing process for Cimicifugae Rhizoma extract and mixed composition thereof are provided, which show improved rate of drug release, bioabsorption rate, and therapeutic effect. CONSTITUTION: The mixing process for the Cimicifugae Rhizoma extract is comprised of: soaking Cimicifugae Rhizoma in 50vol.% of ethanol, compressing the extract, and obtaining the extracted solution; mixing 30-90wt.% of polyethylene glycol 400 and 5- 20wt.% of conc.glycerin in another vessel, adding 5-15wt.% of distilled water, heating, and homogenizing by mixing at 60deg.C; adding 2-40wt.% of Cimicifugae Rhizoma extract, and mixing uniformly while shaking at 1500rpm; cooling to normal temperature while shaking slowly, removing the foam, and producing the mixed composition; and manufacturing capsules by the common process.