HETEROBICYCLIC DERIVATIVES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION

摘要

organic chemistry, pharmacy. SUBSTANCE: invention relates to heterobicyclic derivatives of the formula (I) and their pharmaceutically acceptable salts that show inhibitory activity with respect to phosphodiesterase-IV and suppressing effect on tumor necrotic factor. Invention describes 5 methods of synthesis of derivatives of pyridopyrazine of the formula (I). EFFECT: improved methods of synthesis, valuable biochemical and medicinal properties. 15 cl, 115 ex