N alpha -2-(4-NITROPHENYLSULFONYL)ETHOXYCARBONYL-AMINO ACID FLUORIDES AND PROCESS FOR THE PREPARATION THEREOF

摘要

There are provided by the present invention new N alpha -2-(4-nitrophenylsulfonyl)ethoxycarbonyl-amino acid fluorides as described in the general formula (I) wherein R1 represents hydrogen and R2 may represent hydrogen, isopropyl, 2-methylpropyl, tert-butoxymethyl, benzyl, 2-(tert-butoxycarbonyl)ethyl, 4-(tert-butoxycarbamido)butyl or 4-tert-butoxybenzyl, and process for the preparation thereof. By using the amino acid fluorides according to the present invention, a certain desired peptide may be easily synthesized without activation step.