| 摘要 |
<p>The invention relates to regulatory sequences which impart a specific expression in dendritic cells. The regulatory sequences are isolated from the human fascin gene and also comprise, for example, promoter sequences. The invention also relates to recombinant nucleic acid molecules and vectors, which contain the regulatory sequences, and to preferred embodiments of the recombinant nucleic acid molecules and vectors, which code the antigens or immunoregulatory proteins. The invention additionally relates to host cells, which contain the recombinant nucleic acid molecules or vectors, and to methods for the production thereof. Additional embodiments relate to in-vitro methods for stimulating T cells and for producing T cell-stimulating dendritic cells, and to their formulation as medicaments. Additional medicaments are described which essentially relate to DNA vaccines and to gene-therapeutic medicaments, for example, for the immunization against and for the treatment of infectious diseases, tumors, allergies, Creutzfeldt-Jakob plaques or Alzheimer plaques. Additional inventive medicaments can be used for the targeted modulation of immune responses that is imparted by dendritic cells, for example, for treating autoimmune diseases or transplant rejection. Finally, the invention relates to different uses of the regulatory sequences.</p> |
