The invention relates to polypeptide conjugates comprising a polypeptide exhibiting G-CSF activity and having an amino acid sequence that differs from the amino acid sequence of human G-CSF in at least one specified introduced and/or removed amino acid residue comprising an attachment group for a non-polypeptide moiety, and having at least one non-polypeptide moiety attached to an attachment group of the polypeptide. The attachment group may e.g. be a lysine, cysteine, aspartic acid or glutamic acid residue or a glycosylation site, and the non-polypeptide moiety may e.g. be a polymer such as polyethylene glycol or an oligosaccharide. The conjugate has one or more improved properties such as increased biological half-life and reduced side effects.
申请公布号
WO0151510(A2)
申请公布日期
2001.07.19
申请号
WO2001DK00011
申请日期
2001.01.09
申请人
MAXYGEN APS
发明人
NISSEN, TORBEN, LAUESGAARD;ANDERSEN, KIM, VILBOUR;HANSEN, CHRISTIAN, KARSTEN;MIKKELSEN, JAN, MOELLER;SCHAMBYE, HANS, THALSGAARD