| 摘要 |
<p>The present invention describes antisense nucleic acids compositions comprising sequences complementary to a first and second region in a target nucleic acid. The antisense sequences are designed to hybridize to complementary nucleic acid target regions in a target RNA, and inhibit translation, processing, transport, or binding by proteins or riboproteins. The first and the second target regions may be contiguous or non-contiguous in the target nucleic acid. Target regions include, but are not limited to, AUG, 5' non-translated sequences, translation initiation factor binding sites, ribosome subunit binding sites, Shine Dalgarno sequence, 3' nontranslated sequences, poly-A tail, 3' cleavage site, coding region, intron, intron branch site, intron/exon junction, or splice sequence. Target nucleic acid may be viral, bacterial, animal, human, and plant. Methods for using these antisense compositions include inhibiting translation of an RNA and treating diseases in a cell, an animal, a plant or a human. Pharmaceutical antisense compositions are also described.</p> |
