发明名称 |
METHODS FOR IDENTIFYING ANTI-CANCER DRUG TARGETS |
摘要 |
Methods, transformation constructs, and transgenic animals for identifying anti-tumor agents and anti-tumor drug targets are described. The transformation constructs are used to generate transgenic animals that have altered expression of an oncogene or tumor suppressor gene in a target tissu e that is dispensable for viability and reproduction. In some embodiments, the altered expression results in abnormal proliferation of the target tissue an d normal proliferation in all other tissues. Anti-tumor drug targets can be identified by generating progeny of the transgenic animals that have mutatio ns in various genes. Gene mutations that result in a specific reduction or killing of the target tissue are identified as possible anti-tumor drug targets and are further evaluated. Anti-tumor agents are identified that mim ic the effect of the gene mutations that result in specific reduction of the target tissue. Alternatively, anti-tumor agents can be identified by administering various compounds directly to the transgenic animals, or their progeny, and selecting as putative therapeutic agents, compounds that result in target-tissue specific antiproliferation.
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申请公布号 |
CA2396311(A1) |
申请公布日期 |
2001.07.19 |
申请号 |
CA20012396311 |
申请日期 |
2001.01.10 |
申请人 |
EXELIXIS, INC. |
发明人 |
OLLMANN, MICHAEL MARTIN;KOPCZYNSKI, JENNY;KOPCZYNSKI, CASEY;DUYK, GEOFFREY;KARIM, FELIX D.;FRIEDMAN, LORI |
分类号 |
A01K67/033;C12N15/85;(IPC1-7):C12Q1/00;C12N5/00;G01N33/00;C12Q1/02;A01N43/04;C12N1/20;G01N33/567 |
主分类号 |
A01K67/033 |
代理机构 |
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地址 |
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