发明名称 |
INHIBITORS OF PRENYL-PROTEIN TRANSFERASE |
摘要 |
The present invention is directed to piperazine-containing macrocyclic compounds which inhibit prenylyl-protein transferase, such as farnesyl-protein transferase (FTase), and therefore inhibit the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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申请公布号 |
WO0151494(A1) |
申请公布日期 |
2001.07.19 |
申请号 |
WO2001US00433 |
申请日期 |
2001.01.08 |
申请人 |
MERCK & CO., INC.;DINSMORE, CHRISTOPHER, J. |
发明人 |
DINSMORE, CHRISTOPHER, J. |
分类号 |
A61K31/337;A61K31/415;A61K41/00;C07D498/22;(IPC1-7):C07D498/08 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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