| 发明名称 |
PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT2A RECEPTOR ANTAGONISTS |
| 摘要 |
The invention relates to compounds of formula (I), wherein R<1>, R<2>, X, Y and alk are defined as per claim 1, are potent 5-HT2A antagonists and are suitable for treating psychosis, schizophrenia, depression, neurological disorders, impaired memory, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, eating disorders, such as bulimia and anorexia nervosa, premenstrual syndrome and/or for positively influencing compulsive behaviour (obsessive-compulsive disorder, OCD). |
| 申请公布号 |
WO0151469(A1) |
申请公布日期 |
2001.07.19 |
| 申请号 |
WO2001EP00080 |
申请日期 |
2001.01.05 |
| 申请人 |
MERCK PATENT GMBH;ACKERMANN, KARL-AUGUST;BOETTCHER, HENNING;PRUECHER, HELMUT;VAN AMSTERDAM, CHRISTOPH;SEYFRIED, CHRISTOPH;GREINER, HARTMUT;BARTOSZYK, GERD;HARTING, JUERGEN |
发明人 |
ACKERMANN, KARL-AUGUST;BOETTCHER, HENNING;PRUECHER, HELMUT;VAN AMSTERDAM, CHRISTOPH;SEYFRIED, CHRISTOPH;GREINER, HARTMUT;BARTOSZYK, GERD;HARTING, JUERGEN |
| 分类号 |
C07D215/36;A61K31/444;A61K31/445;A61K31/454;A61K31/47;A61K31/4709;A61K31/496;A61P25/16;A61P25/18;A61P25/24;A61P25/28;C07D209/08;C07D209/40;C07D211/54;C07D213/70;C07D217/02;C07D233/84;C07D271/12;C07D285/14;C07D295/22;C07D295/26;C07D307/91;C07D333/34;C07D333/62;C07D401/04;C07D401/06;C07D401/12;C07D409/06;C07D409/12;C07D409/14;C07D417/12;C07D471/04;C07D513/04 |
主分类号 |
C07D215/36 |
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