发明名称 |
METHODS OF REGULATING IL-12 PRODUCTION BY ADMINISTERING CCR5 AGONISTS AND ANTAGONISTS |
摘要 |
The present invention provides a method for increasing IL-12 production in a cell, comprising administering a CCR5 agonist to the cell. The invention also provides a method for decreasing IL-12 production in a cell, comprising administering a CCR5 antagonist to the cell. Further provided by this invention is a method for treating a disease associated with increased IL-12 production in a subject, comprising administering to the subject a CCR5 antagonist in an amount effective in reducing the disease-associated effect of IL-12, thereby treating the disease associated with increased IL-12 production. Also provided by this invention is a method for increasing IL-12 production in a subject, comprising administering and effective amount of a CCR5 agonist to the subject. |
申请公布号 |
WO0151077(A1) |
申请公布日期 |
2001.07.19 |
申请号 |
WO2000US01019 |
申请日期 |
2000.01.14 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICAREP RESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;SHER, ALAN;ALIBERTI, JULIO, CESAR, SOARES |
发明人 |
SHER, ALAN;ALIBERTI, JULIO, CESAR, SOARES |
分类号 |
A61K38/19;A61P37/00;C07K16/28 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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