O-METHYLATED RAPAMYCIN DERIVATIVES FOR ALLEVIATION AND INHIBITION OF LYMPHOPROLIFERATIVE DISORDERS

摘要

The present invention relates to methods of alleviating and inhibiting a lymphoproliferative disorder in a mammal, the method comprising administerin g one or more rapamycin derivatives (including rapamycin) to the mammal (see figure 8). Further, the invention provides a method for identifying agents which are useful for alleviating and inhibiting lymphoproliferative disorder s, as well as a method for identifying agents which are capable of inhibiting metastasis of lymphatic tumors in a mammal.