发明名称 |
RESPIRATORY SYNCYTIAL VIRUSES EXPRESSING IMMUNE MODULATORY MOLECULES |
摘要 |
Recombinant respiratory syncytial virus (RSV) are provided which express one or more immune modulatory molecules. The recombinant virus is modified by addition or substitution of a polynucleotide sequence encoding the immune modulatory molecule, which is preferably a cytokine. Introduction of the cytokine increase, decrease, or otherwise enhances aspects of viral biology and/or host immune responses to RSV to facilitate vaccine use of the virus. Cytokines for use within the invention include but are not limited to interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL-6), or interleukin 18 (IL-18), tumor necrosis factor (TNF) alpha, interferon gamma (IFN), and granulocyte-macrophage colony stimulating factor (GM-CSF). The polynucleotide or immune modulatory molecule is preferably added or substituted into the recombinant viral genome or antigenome, typically at an intergenic or other non-coding site, as a separate gene but may be otherwise expressed, for example as a fusion protein.
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申请公布号 |
WO0104271(A3) |
申请公布日期 |
2001.07.19 |
申请号 |
WO2000US19042 |
申请日期 |
2000.07.12 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;COLLINS, PETER, L.;BUKREYEV, ALEXANDER;MURPHY, BRIAN, R.;WHITEHEAD, STEPHEN, S. |
发明人 |
COLLINS, PETER, L.;BUKREYEV, ALEXANDER;MURPHY, BRIAN, R.;WHITEHEAD, STEPHEN, S. |
分类号 |
C12N15/09;A61K9/12;A61K35/76;A61K39/00;A61K39/155;A61K48/00;A61P11/00;A61P11/06;A61P31/14;A61P37/04;C07K14/54;C12N7/00;C12N7/04;C12N15/86;(IPC1-7):C12N15/86;C07K14/14;C12N15/62;A61K38/17 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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