Control process for use in chromatographic separations, comprises bonding the materials to be separated on a stationary phase and eluting through a fluid phase using an on-line calculated concentration of components of the material

摘要

A control process comprises bonding the materials to be separated on a stationary phase and eluting through a fluid phase using an on-line calculated concentration of one or more components of the material to be separated in the fluid as an auxiliary parameter. A control process comprises bonding the materials to be separated on a stationary phase and eluting through a fluid phase using an on-line calculated concentration of one or more components of the material to be separated in the fluid as an auxiliary parameter. The calculation of the concentration is carried out through a combination of a rigorous and data-driven model to describe the chromatographic separation of the mixed components.