METHODS FOR IDENTIFYING PERIPHERAL BENZODIAZEPINE RECEPTOR BINDING AGENTS
摘要
The invention provides methods for screening for agents that modulate mitochondrial membrane potential. Such agents generally bind to a peripheral benzodiazepine receptor and may be detected by direct binding assays or by indirect or functional assays. Agents identified using the screens provided herein have application in the prevention and treatment of a variety of diseases associated with abnormal mitochondrial function.