The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
申请公布号
WO0151127(A1)
申请公布日期
2001.07.19
申请号
WO2001US00634
申请日期
2001.01.09
申请人
MERCK & CO., INC.;DESOLMS, S., JANE;STOKKER, GERALD, E.;SHAW, ANTHONY, W.
发明人
DESOLMS, S., JANE;STOKKER, GERALD, E.;SHAW, ANTHONY, W.
