Benzothiophene derivatives and corresponding use and composition

摘要

Benzothiophene derivative compounds and corresponding use and composition; the compounds respond to formula (I):where Z is: -CO-, -CH(OR6)-, -C(NOR7)-; R1 is: H, C1-C6 alkyl, halogen, or -OR8; R2 and R3 are: H, alkyl, halogen, -OR8, nitro, cyano, NR9R10; -COR8; CO2R8; -SO2NR9R10; -SO2R8; -SR8; -CONR9R10; R4 and R5 are: H, alkyl, halogen, haloalkyl, -OR8, nitro, NR9R10; -COR8; CO2R8; -SO2NR9R10; -SO2R8; SR8, cyano; -CONR9R10 or R4 and R5 form a benzene ring; R6 is: H, alkyl, CO2R8, -C(O)NR9R10, naphthyl or phenyl; R7 is: H or alkyl; R8 is H, C1-C6 alkyl or phenyl; R9 and R10 are: H, alkyl or phenyl or R9 and R10 form a 5- or 6-membered ring. These compounds are effective for the treatment of anxiety or depression.